GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry
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چکیده
منابع مشابه
HEMATOPOIESIS AND STEM CELLS GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry
Maintaining hematopoietic stem cell (HSC) quiescence is a critical property for the life-long generation of blood cells. Approximately 75% of cells in a highly enriched long-term repopulating HSC (LT-HSC) pool (Lin Sca1 c-KithiCD150 CD48 ) are quiescent, with only a small percentage of the LT-HSCs in cycle. Transcription factor GATA-3 is known to be vital for the development of T cells at multi...
متن کاملGATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry.
Maintaining hematopoietic stem cell (HSC) quiescence is a critical property for the life-long generation of blood cells. Approximately 75% of cells in a highly enriched long-term repopulating HSC (LT-HSC) pool (Lin(-)Sca1(+)c-Kit(hi)CD150(+)CD48(-)) are quiescent, with only a small percentage of the LT-HSCs in cycle. Transcription factor GATA-3 is known to be vital for the development of T cell...
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ژورنال
عنوان ژورنال: Blood
سال: 2012
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2011-07-366070